Glaucoma
Glaucoma Disease » Glaucoma » Alphagan P

Alphagan P

Question:

In reading the documents related to AlphaganP approval on the government web site, I noticed two interesting facts about the drug: 1 – It in in Pregnancy category B, so seems to be less of a risk for pregnant women than some other glaucoma drugs. 2 – It was not tested on anyone with depression. Depression was grounds for being excluded from the trials. I wonder if any depression side effect comes from the basic chemistry of the drug, and not from the preservative? I understand that it is only a difference in preservative (Purite) that distinguishes it from regular Alphagan. Something is said about using caution in prescribing it to patients with depression.

Response:

In article <20020116033911.23186.00000…@mb-ml.aol.com>, dwallac…@aol.com (David L.W.) writes: > It is a relative >of oral clonidine(Catapres), which is used in hypertension.

hmmmmmmmm that is interesting dave… thanks for the information…

Response:

I’ve been on Alphagan-P for a month (switched from Alphagan) and haven’t noticed side effects. My pressure went from 26 to 20. I also have Cosopt now. Maybe you’re allergic to the different preservative in Alphagan-P? How frustrating for you.. – Hide quoted text — Show quoted text -SAHM2Three wrote: > Ok, as I said earlier, I would report in, once I’d been using the Alphagan P > for a bit.. > I HATE IT….. I don’t know about anyone else, but it’s awful.. It’s even worse > than the original Alphagan…… >  I want to litterally just rip my eyes out of the sockets….  I’ve been using > tears to keep them moisturized to reduce some of the problems I’ve noticed with > the Alphagan, but to no-avail. > My eyes are soooo bloodshot it’s ridiculous….  I look like I’ve been hitting > the bottle all day,a nd for all this aggrivation, I might as well.. <just > kidding>….  and I can’t tell but it looks like I’ve developed little ridgies, > or blisters on the whites of my eyes, in addition to them feeling very very > scratchy and irritated. > The spaciness isn’t so much a problem as it was with the regular Alphagan, but > my eyes hurt so much even closing them makes them feel like I’ve stepped into a > sand pit….. > Ok, there’s my 2 cents worth on the new stuff… Anyone else have a story they > wanna share?????? > Lynn

– A contented malcontent. http://www.equalizers.org

Response:

In article <a338c707.0201242007.70a77…@posting.google.com>, guantaname…@hotmail.com (Faye) writes: >Something is said about using caution in prescribing it to patients >with depression.

oh sheesh, well since it doesn’t take much to depress me, maybe that will be something else I will have to watch out for in addtion to the spacey side affect..  Just dandy candy I’ll tell ya…. Lynn

Response:

My doc said it’s weaker-compare the ingredient %age on the two. JoellynR wrote: > In article <a338c707.0202022242.58741…@posting.google.com>, > guantaname…@hotmail.com (Faye) writes: > >P is weaker than > >regular Alphagan. > Is this true?  I thought the only difference between the two is the difference > in preservative…Leigh

– A contented malcontent. http://www.equalizers.org

Response:

Do you have more info re this? They seem to be distant cousins rather than close ones, if clonidine is used for ADHD, etc. I know they’re both imidazoline derivatives…Thanks "David L.W." wrote: > I also use Alphagan and I frequently feel fatigued from it.  It is a relative > of oral clonidine(Catapres), which is used in hypertension. > –Dave

– A contented malcontent. http://www.equalizers.org

Response:

Hi Group; Tried Lumigan for about a week, but couldn’t handle the constant headaches so Dr switched me to Alphagan P. Would appreciate any comments on Alphagan P. Understand that it just recently came out in the P version to reduce some of the side effects found with the original Alphagan.  Thanks — Outgoing mail is certified Virus Free. Checked by AVG anti-virus system (http://www.grisoft.com). Version: 6.0.303 / Virus Database: 164 – Release Date: 11/24/01

Response:

I also use Alphagan and I frequently feel fatigued from it.  It is a relative of oral clonidine(Catapres), which is used in hypertension. –Dave

Response:

Alphagan-p is now out. It has a different preservative and is supposed to have fewer side effects but the same efficacy as old Alphagan. I’ll be switching to it this week from Alphagan so will let you know my opinion. – Hide quoted text — Show quoted text -olf wrote: > Thanks. Also interested in comments from persons using Alphagan > "Norman" <u…@node.com.invalid> wrote in message > news:r40j1uotr676evf2ug11d33af2sqf5rdib@4ax.com… > > On Sun, 2 Dec 2001 20:09:08 -0500, "olf" <olf_…@excite.com> wrote: > > >Dr switched me to Alphagan P. Would appreciate any comments on Alphagan > > >P. Understand that it just recently came out in the P version to reduce > some > > >of the side effects found with the original Alphagan.  Thanks > > Well, I checked Allergan’s Alphagan website, and it hasn’t been updated > since > > July 2000. > > I found out that Alphagan P (brimonidine tartrate ophthalmic solution), > 0.15% > > was approved by the FDA on 16 Mar 2001. You can find some of the approval > > documentation at: > > http://www.fda.gov/cder/foi/nda/2001/21-262_AlphaganP.htm > > I doubt that I’ll understand enough to make the experience worthwhile. > Good > > luck. > > Here’s Allergan’s Press Release on Alphagan P. > > http://www.allergan.com/corpinfo/press/content/pr031901.htm > > Sorry. Couldn’t find any more info on it beyond the standard Alphagan > info. > > – — > > Norman > > Please reply via group. > > e-mail ID does not exist.

– A contented malcontent. http://www.equalizers.org

Response:

Thanks. Also interested in comments from persons using Alphagan "Norman" <u…@node.com.invalid> wrote in message

news:r40j1uotr676evf2ug11d33af2sqf5rdib@4ax.com… – Hide quoted text — Show quoted text -> On Sun, 2 Dec 2001 20:09:08 -0500, "olf" <olf_…@excite.com> wrote: > >Dr switched me to Alphagan P. Would appreciate any comments on Alphagan > >P. Understand that it just recently came out in the P version to reduce some > >of the side effects found with the original Alphagan.  Thanks > Well, I checked Allergan’s Alphagan website, and it hasn’t been updated since > July 2000. > I found out that Alphagan P (brimonidine tartrate ophthalmic solution), 0.15% > was approved by the FDA on 16 Mar 2001. You can find some of the approval > documentation at: > http://www.fda.gov/cder/foi/nda/2001/21-262_AlphaganP.htm > I doubt that I’ll understand enough to make the experience worthwhile. Good > luck. > Here’s Allergan’s Press Release on Alphagan P. > http://www.allergan.com/corpinfo/press/content/pr031901.htm > Sorry. Couldn’t find any more info on it beyond the standard Alphagan info. > – — > Norman > Please reply via group. > e-mail ID does not exist.

Response:

In article <a338c707.0202022242.58741…@posting.google.com>, guantaname…@hotmail.com (Faye) writes: >but had a lot of >spaciness on regular Alphagan.

yes Faye, so did I, and it was awful.. I could barely function during the day, so I discontinued use during the day and only took it at night, then I had a very hard time getting up in the morning and actually functioning …. by mid morning the affect wore off and If elt more normal. Lynn

Response:

In article <3C7401C0.99F66…@equalizers.org>, Carolyn Schwebel <c…@equalizers.org> writes: >Maybe you’re allergic to the different preservative in Alphagan-P? How >frustrating >for you..

Carolyn, that is what I am thinking too.. While the Regular Alphagan made me very tired and I had to drop it until night time, it did not have these horrible side affects the Al-P is causing.. Of course I quit taking it, until we can figure something else out. I am tired of those little blisters on my eyes… ouch… Lynn

Response:

On Sun, 2 Dec 2001 20:09:08 -0500, "olf" <olf_…@excite.com> wrote: >Dr switched me to Alphagan P. Would appreciate any comments on Alphagan >P. Understand that it just recently came out in the P version to reduce some >of the side effects found with the original Alphagan.  Thanks

Well, I checked Allergan’s Alphagan website, and it hasn’t been updated since July 2000. I found out that Alphagan P (brimonidine tartrate ophthalmic solution), 0.15% was approved by the FDA on 16 Mar 2001. You can find some of the approval documentation at: http://www.fda.gov/cder/foi/nda/2001/21-262_AlphaganP.htm I doubt that I’ll understand enough to make the experience worthwhile. Good luck. Here’s Allergan’s Press Release on Alphagan P. http://www.allergan.com/corpinfo/press/content/pr031901.htm Sorry. Couldn’t find any more info on it beyond the standard Alphagan info. – — Norman Please reply via group. e-mail ID does not exist.

Response:

Ok, as I said earlier, I would report in, once I’d been using the Alphagan P for a bit.. I HATE IT….. I don’t know about anyone else, but it’s awful.. It’s even worse than the original Alphagan……  I want to litterally just rip my eyes out of the sockets….  I’ve been using tears to keep them moisturized to reduce some of the problems I’ve noticed with the Alphagan, but to no-avail. My eyes are soooo bloodshot it’s ridiculous….  I look like I’ve been hitting the bottle all day,a nd for all this aggrivation, I might as well.. <just kidding>….  and I can’t tell but it looks like I’ve developed little ridgies, or blisters on the whites of my eyes, in addition to them feeling very very scratchy and irritated. The spaciness isn’t so much a problem as it was with the regular Alphagan, but my eyes hurt so much even closing them makes them feel like I’ve stepped into a sand pit….. Ok, there’s my 2 cents worth on the new stuff… Anyone else have a story they wanna share?????? Lynn

Response:

In article <a4kiph$106j…@ID-34582.news.dfncis.de>, "olf" <olf_…@excite.com> writes: >Hang in there. Hope you and your Dr can find a med that you can tolerate. >Good Luck

thanks so much. I sure hope so as well. In the meantime, I’m keeping up with my trupsopt and xylatan…  it’s just so frustrating to spend the money on medication then not being able to use it…they had no samples to try.. hehehe OH well, Lynn

Response:

Been using AlphaganP for several weeks now (since my 1st post). Just went for a checkup and the pressures of around 22-24 are now down to 16 (use twice a day) so it must be doing the job. The main side effect that I had was being constantly tired (exhausted for the first week) but my system must be adjusting since that has improved alot. — Outgoing mail is certified Virus Free. Checked by AVG anti-virus system (http://www.grisoft.com). Version: 6.0.313 / Virus Database: 174 – Release Date: 1/2/02

Response:

In article <a1l1ul$r3o2…@ID-34582.news.dfncis.de>, "olf" <olf_…@excite.com> writes: >The main side effect that I had >was being constantly tired

the tiredness was part of the problem when I used the Alphagan regular.. Does it still cause the drowsiness during the daytime?? OH i hope not, otherwise, I’m gonna have major problems…. Lynn

Response:

I’ve been using Alphagan P for 3 1/2 months. For the first week or two I was extremely fatigued and sleepy all the time. This side effect has since vanished and I have only good things to say about the med. Use twice a day and pressures have dropped from around 27 to 16. No discoloration or discomfort. I have always has sinus problems and I find that if I am not careful when applying the drops and allow it to enter the tear ducts, I do have some increased sinus drainage, but that is the only problem. Sorry you are having problems. Just shows how meds affect different people. I had problems similar to yours with Lumigan, yet I know people who tolerate Lumigan very well. Hang in there. Hope you and your Dr can find a med that you can tolerate. Good Luck "SAHM2Three" <sahm2th…@aol.com> wrote in message

news:20020215215642.17828.00001163@mb-fn.aol.com… – Hide quoted text — Show quoted text -> Ok, as I said earlier, I would report in, once I’d been using the Alphagan P > for a bit.. > I HATE IT….. I don’t know about anyone else, but it’s awful.. It’s even worse > than the original Alphagan…… >  I want to litterally just rip my eyes out of the sockets….  I’ve been using > tears to keep them moisturized to reduce some of the problems I’ve noticed with > the Alphagan, but to no-avail. > My eyes are soooo bloodshot it’s ridiculous….  I look like I’ve been hitting > the bottle all day,a nd for all this aggrivation, I might as well.. <just > kidding>….  and I can’t tell but it looks like I’ve developed little ridgies, > or blisters on the whites of my eyes, in addition to them feeling very very > scratchy and irritated. > The spaciness isn’t so much a problem as it was with the regular Alphagan, but > my eyes hurt so much even closing them makes them feel like I’ve stepped into a > sand pit….. > Ok, there’s my 2 cents worth on the new stuff… Anyone else have a story they > wanna share?????? > Lynn

— Outgoing mail is certified Virus Free. Checked by AVG anti-virus system (http://www.grisoft.com). Version: 6.0.324 / Virus Database: 181 – Release Date: 2/14/02

Response:

I asked my glaucoma doctor about AlphaganP versus regular Alphagan side effects, as the P version is said to have fewer side effects due to use of a different preservative. However, any spaciness or depression experienced while on Alphagan were due to the drug, he said, not the preservative. So these could be expected on the P version, too, though perhaps in a milder form since P is weaker than regular Alphagan. Hope this helps! I was considering AlphaganP to help get my pressures down that last bit to the target, but had a lot of spaciness on regular Alphagan. Faye

Response:

In article <a338c707.0202022242.58741…@posting.google.com>, guantaname…@hotmail.com (Faye) writes: >P is weaker than >regular Alphagan.

Is this true?  I thought the only difference between the two is the difference in preservative…Leigh

Response:

My doctor switched me to Alphagan P from Alphagan, so I’ll be posting my 2 cents worth as well… hope it doesn’t cost more…. Lynn

Response:

Related Posts

Write a comment