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Information about latanoprost

Question:

bo…@tiac.net (Ray Bonar) wrote: >Hi Peggy; >Dr. Robert Ritch responds that Latanoprost (Xalatan) is a very >effective drug. However, like all antiglaucoma drugs, there are high >responders, low responders and nonresponders.

What about adverse responders? >This probably will >eventually indicate something about the molecular biology of the >glaucoma itself, i.e., that there are presently undetectable different >diseases at a molecular level.

Why should *this* drug indicate this more than other drugs?  Does Dr. Ritch think counting "diseases" (or angels on the heads of pins) improves people’s health?  Actually, almost by definition (if ‘disease’ has any), diseases don’t occur at molecular levels. >The abstract of the presentation we gave at ARVO a couple of weeks ago >is below. In the meantime, it has been noted that patients taking >latanoprost are developing thicker, more numerous, longer and darker >eyelashes. A number of ophthalmologists are now putting latanoprost on >their heads.

Gee, I sure hope that makes them think just a little bit better.  Hmm. But how can we make them think more in the public’s interest? BTW, when hair starts growing from  your irides, you’re using too high a dosage of latanoprost.  =;-) – Hide quoted text — Show quoted text ->Petelska B, Greenfield DS, Liebmann JM, Wand M, Kushnick H, Ritch R: >Latanoprost for uncontrolled glaucoma. A compassionate case study. Am >J Ophthalmol, in press. >Purpose. To evaluate the ocular hypotensive response of latanoprost >0.005% administered as adjunctive therapy in patients with glaucoma >receiving maximal tolerated medical therapy. >Methods. Consecutive patients entering a latanoprost compassionate >clinical trial were enrolled at two sites. Latanoprost 0.005% was >administered as a single drop between 6:00 and 8:00 P.M. and all other >medications were continued. Intraocular pressure (IOP) was measured >between 2:00 and 4:00 P.M. Responders were defined as a reduction in >IOP of at least 20% from baseline. >Results. In 160 eyes of 160 patients on maximal tolerated medical >therapy, mean baseline IOP was 23.3

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